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The Journal of Immunology, 1971, 106: 1559-1565.
Copyright © 1971 by The American Association of Immunologists, Inc.
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A New Specific Humoral Viral Resistance Factor, Serum Protective Factor—Some Biologic and Physical Properties1

Inderjit S. Thind and Winston H. Price

From the Kenneth F. Maxcy Laboratories, Department of Epidemiology, School of Hygiene and Public Health, The Johns Hopkins University, Baltimore, Maryland 21205

Abstract

Serum protective factor (SPF) is a new specific humoral viral resistance substance found in mice following certain experimental arbovirus infections. This factor occurs with or without the use of the immunosuppressant drug cyclophosphamide. A further characterization of its physical and biologic properties is presented. SPF, a protein with an estimated molecular weight of between 67,000 and 150,000, persists for a longer period of time than neutralizing antibody and interferon following primary Langat virus infection of mice. SPF is different from the well characterized imunoglobulins as suggested by Sephadex G-150 column fractionation, and has no in vitro virus neutralizing activity in contrast to neutralizing antibody. Unlike neutralizing antibody, SPF requires living cells to protect in vivo and does not protect mice younger than 14 days of age on passive administration against subsequent viral challenge. Thus in recovery from viral infections, humoral substances such as SPF, interferon and neutralizing antibody may have a synergistic action since the former two protect by their action on the cells and the latter acts directly on the virus to provide protection.

Footnotes

1 This work was supported by the Office of the Surgeon General, United States Department of the Army, Contract DA-49-193-MD-2398.






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