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Complement Fixation in Conventional and Regressing Virus-Induced Murine Leukemia¹

From the Department of Cell Biology, Research Laboratories, Albert Einstein Medical Center, Philadelphia, Pennsylvania 19141

Abstract

Immunization of Swiss mice with conventional strains of murine leukemia virus did not elicit an appreciable humoral complement fixation (CF) response. In contrast, CF antibody was observed in mice infected with a virus that induced a spontaneously regressing leukemia. After infection with regressing Friend virus, (RFV), CF antibody was present in mice in which leukemia had regressed but was absent in leukemic mice. CF antibody elicited by RFV cross-reacted with other strains of murine leukemia virus.

Footnotes

¹ This work was supported by United States Public Health Service Grant CA-06711 from the National Cancer Institute.

² Research Career Development Awardee (1-K3-CA21773) of the National Cancer Institute, National Institutes of Health.

³ Present address: New York Institute for Basic Research in Mental Retardation, Staten Island, New York, 10314.

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				P Furmanski, J Baldwin, R Clymer, and M. Rich Spontaneous regression of friend virus induced leukemia: coinfection with regressing and conventional strains of virus Science, January 10, 1975; 187(4171): 72 - 73. [Abstract] [PDF]