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The Effect of Sensitized Lymphocytes on Peritoneal Exudate Macrophages in the Guinea Pig¹

From the Department of Pathology, State University of New York at Buffalo, Buffalo, New York 14214

Abstract

The injection of antigen into the peritoneal cavity of delayed hypersensitive guinea pigs bearing peritoneal exudates leads to a marked reduction in the macrophage content of these exudates. Lymphocytes from immunized donors can confer this property on glycogen-induced exudates in non-immunized recipients. The reaction appears to represent an in vivo analog of the well-known migration inhibition reaction.

Footnotes

¹ This work was supported, in part by Grant AI-09114 from the National Institutes of Health, and by funds from a Dr. Henry C. and Bertha H. Buswell Fellowship.

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