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The Number of Antibody-Producing Cells in the Parathymic Lymph Nodes and the Spleen Following Intraperitoneal Injection of Antigen¹

From the Department of Medical Microbiology and the Fleischmann Laboratories, Stanford University School of Medicine, Stanford, California 94305

Abstract

Following i.p. injection of antigen in the rat, the parathymic lymph nodes are major, if not the major, site of antibody-producing cells. Though they contain only one-tenth the number of nucleated cells, these nodes have essentially as many antibody-forming cells as does the entire spleen. Technical limitations that occur when the spleen is employed for such studies are also minimized or absent when the PLN are used to determine the number of PFC by the modified Cunningham technique. Thus, the parathymic lymph nodes should receive increased attention in investigating the cellular kinetics of the immune response.

Footnotes

¹ This work was supported in part by Training Grant AI-00082 and Research Grant AI-02755 from the National Institutes of Health, United States Public Health Service, and by a research grant from the Veterans Administration.