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Primate Respiratory Mast Cells

Reactions with Ascaris Antigen and anti-Heavy Chain Sera¹

From the Section of Allergy-Immunology, Department of Medicine, Northwestern University-McGaw Medical Center, Chicago, Illinois

Abstract

Mast cells were obtained from the bronchi of a group of monkeys with varying degrees of cutaneous and respiratory hypersensitivity to purified ascaris antigen. The respiratory tissue biopsies were repeated many times on the same subjects. The mast cells were identified in both fixed and living preparations of respiratory mucosa which were maintained under short-term tissue culture conditions. The living mast cells in respiratory tissue exposed to rabbit anti-human IgE and Compound 48/80 underwent morphologic changes of degranulation. Respiratory mast cells from rhesus monkeys with a sufficient degree of in vivo respiratory and cutaneous reactivity to ascaris antigen had similar loss of granules after exposure to antigen in vitro. The loss of granules resulted from their intracellular disappearance rather than extrusion from the mast cells. Treatment of the cells with anti-IgG caused some degranulation of mast cells, but to a lesser extent than was observed with anti-IgE, ascaris antigen or Compound 48/80.

Footnotes

¹ This work was supported by the Ernest S. Bazley Grant to Chicago Wesley Memorial Hospital and the Northwestern University.

This article has been cited by other articles:

				R. Patterson, L. R. Head, I. M. Suszko, and C. R. Zeiss Jr. Mast Cells from Human Respiratory Tissue and Their in vitro Reactivity Science, March 3, 1972; 175(4025): 1012 - 1014. [Abstract] [PDF]