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Deposition of Immune Complexes in the Kidneys of Mice Infected with Lactic Dehydrogenase Virus¹

From the Department of Pathology, University of California at Los Angeles School of Medicine, Los Angeles, California 90024

Abstract

Mice showed renal glomerular deposition of immunoglobulin and complement as early as 7 days after infection with lactic dehydrogenase virus, concomitant with the appearance of circulating antibody. Immunoglobulin eluted from the kidneys contained virus-specific antibody. A minimal histologic alteration of glomeruli was observed despite the immune complex deposition.

Footnotes

¹ This work was supported by Grant AI-09476 from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, and a grant from the California Institute for Cancer Research.