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The Response in Rabbits to Prolonged Immunization with Type III Pneumococci¹

From The Biological Laboratories, Harvard University, Cambridge, Massachusetts

Abstract

Every rabbit in a group of 17 animals immunized with formalinized type III pneumococci produced type-specific antibody of restricted electrophoretic heterogeneity. The critical factor in eliciting this response appears to be repeated antigenic stimulation over a period of many weeks rather than a particular genetic constitution of the animals. Over long periods of time and with continued immunization, restricted components appear and disappear as shown by 1) the appearance and disappearance of antibody populations of a distinct, restricted electrophoretic mobility and 2) the parallel behavior of the corresponding light chains. Two animals that produced extraordinarily high concentrations of antibodies (43 and 68 mg/ml of serum) showed clinical signs strikingly similar to those associated with multiple myeloma in man.

Footnotes

¹ This investigation was supported in part by Grant GB-18919 from the National Science Foundation.

² Recipient of a United States Public Health Service Special Fellowship 5 FO3 GM43373-02 from the National Institute of General Medical Sciences.

³ Cardiac Unit, Massachusetts General Hospital, Boston, Massachusetts 02114.