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The Journal of Immunology, 1971, 106: 1154-1158.
Copyright © 1971 by The American Association of Immunologists, Inc.
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In Vitro Effects of Measles Virus on Proliferating Human Lymphocytes

Burton Zweiman

From the Allergy and Immunology Division, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104

Abstract

Addition of measles virus to human lymphocytes cultured with phytohemagglutinin-P or antigen in medium containing fetal calf serum depressed the usual proliferative response in cells of both measles-immune and measles-susceptible subjects. When antologous serum was used in the medium, measles virus-induced depression of proliferation was seen only in cells of measles-susceptible individuals. The latter finding suggests inhibition of the measles virus effect by anti-measles antibodies or other humoral factors in the serum of measles-immune individuals.




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