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Passive Transfer of Delayed Hypersensitivity in Guinea Pigs: Role of Conventional Antibody and Antigen¹

From the Pediatric Research Laboratories of the Variety Club Heart Hospital, University of Minnesota, Minneapolis, Minnesota 55455

Abstract

Plasma from irradiated sensitized donors will passively transfer delayed hypersensitivity to DNP-BSA. The transfer is specific and cannot be attributed to transfer of demonstrable ₁ or ₂ antibodies, antigen or super-antigen of DNP-BSA specificity.

Footnotes

¹ This work was aided by grants from the American Thoracic Society, The National Foundation-March of Dimes, United States Public Health Service (NB-02042, AI-08677), American Cancer Society and American Heart Association.

² Supported by fellowships from the Commissariat Général du Plan d'Equipement et de la Productivité (France), the University of Minnesota, and the Eli Lilly Company. Present address: Unité de recherches de'hépatologie infantile-Laboratoire d'immunologie Bicêtre, France.

³ American Legion Memorial Research Professor, Regents' Professor of Pediatrics and Microbiology, University of Minnesota.