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Observations on a Human Antiglobulin of Intermediate Type¹

From the Laboratory of Immunology, Children's Hospital, Bristol BS2, 8BJ, England, and the Section of Hematology and Immunology, Department of Medicine, University of California School of Medicine, San Francisco, California 94122

Abstract

Antiglobulin Fi. reacts with its own IgG, with some human IgG's of all four subclasses and with rabbit antibody IgG. The determinant is present in the sera of all races tested. It has also been found in the sera of apes and Cercopithecus monkeys, but only in a few high-titer anti-D IgG. It is present in cord serum and serum of aged subjects but is present in very small amounts, if at all, in early fetal sera. It is tentatively assumed that it is present in a basic amino acid sequence of the Fc fragment of the heavy chain of IgG.

Footnotes

¹ This work was supported by grants from the United States Public Health Service (AI-08527 and AI-09134), Action for Crippled Children, London, England, and a grant from the American Cancer Society (T386).