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The Antigen Receptor in Delayed-Type Hypersensitivity

I. Isolation with an Affinity Label¹

From the Trudeau Institute, Saranac Lake, New York 12983

Abstract

Antigen-specific receptors have been demonstrated on lymphoid cells from guinea pigs sensitized to give delayed-type hypersensitivity reactions. A unique affinity label was used to trace the reactive molecule. After solubilization of the cell membrane, two specifically labeled components of restricted molecular weight were isolated by chromatographic methods.

Footnotes

¹ This work was supported by Grant AI-07015, National Institute of Allergy and Infectious Diseases, United States Public Health Service.

² Richard Remsen Fellow.