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Immune Hemolysis and the Functional Properties of the Second (C2) and Fourth (C4) Components of Complement

II. Clustering of Effective C Complexes at Individual Hemolytic Sites

From the Institute of Medical Microbiology, J. Gutenberg University, Mainz, West Germany, and the Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda Maryland 20014

Abstract

On the cell intermediate EAC142, made with limited C1, excess C4 and excess C2, more than one (up to six) hemolytically effective
complexes may be present at a single SAC1, i.e.,
complexes cluster at a singl hemolytice site. These cells lyse more rapidly, utilize C-EDTA more efficiently and have more C3 convertase activity per hemolytic site than EAC142 made with excess C1 and C4 and limited C2, although both cell types lyse to the same extent with excess C-EDTA. Multiple
complexes per hemolytic site were generated with guinea pig and with human C1, C4 and C2.

Footnotes

¹ Guest worker in the Biology Branch, National Cancer Institute. Supported by the Deutsche Forschungsgemeinschaft, Op 12/5.