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Studies on the Cellular Basis for Partial Tolerance: Antigen-Specific Suppression of Antigen-Induced Thymidine-2-¹⁴C Incorporation In Vitro¹

From the Department of Medicine, Tufts University School of Medicine, New England Medical Center Hospital, Boston, Massachusetts, and the Department of Medicine, Harvard Medical School, Beth Israel Hospital, Boston

Abstract

The suppression of delayed hypersensitivity by induction of partial immunologic tolerance is antigen-specific both in vivo and in vitro. Lymph node cells from partially tolerant animals incorporate thymidine-2-¹⁴C either poorly or not at all in response to antigenic challenge in vitro. The latter response more closely parallels the diminution of delayed skin reactivity than the decrease in antibody production in partially tolerant animals.

Footnotes

¹ These studies were supported by the National Institutes of Health, Department of Health, Education and Welfare, Grant AM-07937, and by National Science Foundation Grant GB-6675K, and United States Public Health Service Grant AI-09003.

² Scholar of the Leukemia Society of America.

³ Recipient of Career Development Award KO 3 HE 11666 from the United States Public Health Service.