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Protein Biosynthesis in the Spleen

II. Effect of Primary Immunization on the Mechanism of Protein Synthesis¹

From the Department of Medicine, University of Tennessee Medical Units, Memphis, Tennessee 38103

Abstract

Spleen microsomes and ribosomes are more efficient for the incorporation of amino acids after primary immunization. Studies undertaken in an attempt to elucidate the mechanism responsible for this observation demonstrated that the functional change is not an integral part of the ribosomal unit, since it can be altered with salt washes. It was postulated that the process of immunization affects the concentration of factors in close association with the ribosomes and thus exerts a control at one of the steps in the mechanism of protein synthesis.

Footnotes

¹ This report is taken in part from a doctoral dissertation submitted in partial fulfillment of the requirements for the Ph.D. degree to the Faculty of the Graduate School of State University of New York at Buffalo, and was supported by a research grant from the American Cancer Society (E-458) and by a Graduate Training Grant from the National Institute of Arthritis and Metabolic Diseases (AM05497). H.S.S. is a recipient of a Special Post-Doctoral Fellowship from the National Institutes of Health (6-FO3-CA-40,010-OIAI).

² Present Address: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland.

³ Requests for reprints should be addressed to this author.