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Study of the Interaction of Concanavalin A with Staphylococcal Teichoic Acids¹

From the Department of Microbiology, Northwestern University Medical School, Chicago, Illinois 60611

Abstract

The interaction of Concanavalin A with teichoic acids from S. aureus and S. epieermidis has been studied by gel diffusion and precipitation in a fluid system. It was found that Concanavalin A reacted with alpha-glucosylated but not with beta-glucosylated teichoic acids from S. epidermidis. It was similarly found that Concanavalin A reacted only with the alpha-linked N-acetylglucosamine teichoic acids from strains of S. aureus. These observations were substantiated by quantitative precipitin and hapten inhibition studies using specific antisera to the staphylococcal strains studied. The usefulness of the interaction of Concanavalin A with teichoic acids in studying the immunochemistry of these antigens was demonstrated.

Footnotes

¹ This work was supported in part by United States Public Health Service Grant AI 07716 and by Microbiology Training Grant 5T1-GM-724 from the National Institute of General Medical Sciences.

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