HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Dupuy, J. M. Articles by Good, R. A. Search for Related Content PubMed Articles by Dupuy, J. M. Articles by Good, R. A.

Role of Lymphoid Cells in Passive Transfer with Plasma of Delayed Hypersensitivity in Guinea Pigs¹

From the Pediatric Research Laboratories of the Variety Club Heart Hospital, University of Minnesota, Minneapolis, Minnesota 55455

Abstract

Specific skin reactions to purified protein derivatives could frequently be transferred with plasma or serum from heavily irradiated sensitized guinea pigs. Splenic lymphocytes from a non-sensitized animal that had been incubated for 90 minutes with plasma capable of transferring sensitivity became able to effect such a transfer. Latex particles, red blood cells, or thymocytes could not effect the transfer nor could spleen cells treated in vitro with large amounts of mitomycin C. It is concluded that only certain lymphoid cells may have receptors at their surfaces for attachment of the factor that is responsible for transferring sensitivity, and that the viability and the ability of these cells to replicate are essential for the passive transfer of delayed hypersensitivity.

Footnotes

¹ This work was aided by grants from the American Thoracic Society, The National Foundation-March of Dimes, U. S. Public Health Service (NB-02042, AI-08677), American Cancer Society, and American Heart Association.

² J. M. D. was supported by fellowships from the Commissariat Général du Plan d'Equipement et de la Productivité (France), the University of Minnesota, and the Eli Lilly Company. Present address: Unité de recherches d'hépatologie infantile—Laboratoire d'immunologie, Bicêtre, France.

³ American Legion Memorial Research Professor, Regents' Professor of Pediatrics and Microbiology, University of Minnesota.