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Apparent False-Positive Reactions in a Serologic Test for Syphilis and Presence of Antinuclear Factor in Hybrids of NZB and A/J Mice¹

From the Venereal Disease Research Laboratory, Venereal Disease Branch, State and Community Services Division, National Communicable Disease Center, Health Services and Mental Health Administration, Public Health Service, United States Department of Health, Education, and Welfare, Atlanta, Georgia 30333

Abstract

NZB mice and their hybrids develop many features resembling human autoimmune disease. Apparent false-positive reactions in a routine cardiolipin-antigen serologic test for syphilis (rapid plasma reagin (18-mm circle) card test) were found in 32.3% of male and 2.0% of female (A/J x NZB)F₁ mice, and also in a small percentage of NZB mice and F₂ hybrids. Antinuclear factor was also found in the serum of a significant percentage of the animals. The (A/J x NZB)F₁ hybrids may be useful as models for the study of the false-positive serologic tests for syphilis which occur in autoimmune disease.

Footnotes

¹ Trade names are used for identification only and do not represent an endorsement by the Public Health Service or the United States Department of Health, Education, and Welfare.