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The Journal of Immunology, 1970, 105: 1082-1086.
Copyright © 1970 by The American Association of Immunologists, Inc.
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Immunochemical and Biologic Properties of Rat IgE

I. Immunochemical Identification of Rat IgE1

Daniel J. Stechschulte2, Robert P. Orange3 and K. Frank Austen

From the Department of Medicine, Harvard Medical School at the Robert B. Brigham Hospital, Boston, Massachusetts 02120

Abstract

An electrophoretically fast, antigenically unique rat immunoglobulin with hapten specificity has been identified and termed IgE. Monospecific antiserum for rat IgE removed from rat antiserum the biologic activities attributed to rat homocytotropic antibody. Thus, the immunoglobulin class of rat homocytotropic antibody is IgE.

Footnotes

1 This work was supported by Grants AI-07722 and FR-05669 from the National Institutes of Health, and a grant from the John A. Hartford Foundation, Inc.

2 Postdoctoral Fellow of the National Arthritis Foundation.

3 Postdoctoral Research Fellow of the Helen Hay Whitney Foundation.






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