HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Oldstone, M. B. A. Articles by Dixon, F. J. Search for Related Content PubMed Articles by Oldstone, M. B. A. Articles by Dixon, F. J.

Persistent Lymphocytic Choriomeningitis Viral Infection

III. Virus-anti-Viral Antibody Complexes and Associated Chronic Disease following Transplacental Infection¹

From the Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California 92037

Abstract

Mice naturally infected transplacentally with lymphocytic choriomeningitis virus carry high titers of virus in their blood and tissues, make anti-viral antibody, and develop an associated chronic disease. The virus travels in the circulation in virus-IgG-complement(C) complexes. A study of the renal glomeruli of such transplacentally infected mice showed the presence of viral antigen, C3 and Ig at birth, and a progressive accumulation of virus-Ig complexes that led to death from glomerulonephritis in some mice by 2 weeks of age.

Footnotes

¹ This is publication 413 from the Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California. This research was supported by United States Public Health Service Grants AI-09484 and AI-07007.

² Recipient of Career Development Award I KO4-A1 42580 AID from the United States Public Health Service.