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Immunologic Detection of Single-Stranded DNA in Adeno-Associated Satellite Virions¹

From the Department of Medicine, University of California at Los Angeles, School of Medicine, and Department of Virology and Epidemiology, Baylor College of Medicine, Houston, Texas

Abstract

Double diffusion experiments with antibodies to single-stranded (s-s) DNA confirmedphysicochemical data that adeno-associated satellite virions contain s-sDNA but the DNA extracted from such virions is double-stranded. Positive immunologicreactions of intact virions with sera from man and mouse with "autoimmune"disease and specifically immunized rabbits are consistent with the hypotheticalrole if viruses as immunogens or as the antigenic participants of immunecomplexvasculitis.

Footnotes

¹ Aided by Research Grants HE 05435 from theNational Heart Institute, CA 04600 from theNational Cancer Institute, National Institutesof Health, United States Public Health Service,and United States Public Health Service ResearchGrant AM 11170.