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An Immunologic Marker Technique for the Cendehill Vaccine Strain of Rubella Virus

From the University of She~eld, Virus Research Laboratory, Lodge Moor Hospital and the Department of Medical Microbiology, Sheffield University, Sheffield, England

Abstract

Rabbits were immunized with serial, intramuscular doses of low tissue culture passage"wild" and high passage "attenuated" strains of rubella virus. Rubella hemagglutination-inhibiting antibody was detected in animals immunized with two serialdoses of 3 log₁₀ TCD₅₀/ml of low passage strains. However, no antibody was detectedin animals immunized with 3 log₁₀ TCD₅₀/ml of the Cendehill vaccine strain of rubellavirus. A reisolate virus from a person immunized with Cendehill rubella vaccine alsohad markedly reduced immunogenic properties in the rabbit. Experiments indicatedthat the Cendehill vaccine virus had a markedly decreased ability to infect rabbits bythe intranasal route. The technique may be a useful marker test for this strain of rubellavaccine. The RA/27/3 and the HPV 77 rubella vaccine strains also had a reducedimmunogenicity for rabbits but the results were too variable to be used as amarker test for these two strains.