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Antigenicity of Polypeptides (Poly Amino Acids): Immunogenicity of a Homopolymer Derivative¹

From the Department of Biochemistry, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107

Abstract

The -2-N ethyl morpholinyl derivative of the homopolymer polyglutamic acid (PAMEG) was immunogenic in rabbits but not in mice or humans. The specificity of the PAMEG-anti PAMEG reaction has been shown. The immunogenic behavior of PAMEG is analogous to polymers of D amino acids.

Footnotes

¹ This work was supported by Contract DADA17-67-C-7021 from the Department of the Army, Office of the Surgeon General and United States Public Health Service Grants AI-07825 and TIAI-00334 from the National Institute of Allergy and Infectious Diseases. Paper 35 in a series of Antigenicity of Polypeptides (Poly Amino Acids).