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Presence of Allotypic Specificities of Three Loci, a, b and f, on Individual Molecules of Rabbit Colostral A Immunoglobulin¹

From the Department of Preventive Medicine and Community Health and the Department of Microbiology, University of Illinois at the Medical Center, Chicago, Illinois 60680

Abstract

Colostral A isolated from 12 rabbits of different genotypes were analyzed individually by quantitative radioprecipitation for the number of molecules bearing allotypic specificities of the a, b and f loci. In these experiments, the minimum percentage of molecules bearing allotypic specificities of all three loci ranged from 38% to 78% with the median sample at 69% as calculated from the percentage of molecules precipitable by each antiserum.

Footnotes

¹ This investigation was supported in part by United States Public Health Service Grants AI 07043-04 and AM 11914-02.

² Supported by United States Public Health Service Training Grant T01-AI-00335 from the National Institute of Allergy and Infectious Diseases.