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Ontogeny of Cell Populations Required for Immunocompetence¹

From the Department of Immunology, University of California, Berkeley, California and the Roswell Park Memorial Institute, Buffalo, New York

Abstract

Differentiation from cellular progenitors of two cell populations required for the immune response to sheep erythrocyte antigens was studied. The receptor-bearing population differentiates from bone marrow progenitors much more rapidly than the peripheral thymic population. The differentiation from bone marrow progenitors of the cells with receptors for antigen is completely independent of thymus, while the differentiation of the peripheral thymic population is dependent upon thymus function. Peyer's patches may not be considered solely as primary lymphoid organs. Peyer's patches in adults have all the cell populations required for immunocompetence. In addition, Peyer's patches cannot be considered the initial source in the neonatal period of the cells with receptors for antigen, because these cells are present in the prenatal period in fetal liver.

Footnotes

¹ This work was supported by General Research Support Grant FR-05648 from the Division of Research Facilities and Resources, and Grant AI-08899, National Institute of Allergy and Infectious Diseases, National Institutes of Health.

² Present address: Department of Biochemistry, Stanford University, Palo Alto, California.

³ Present address: Associated Biomedic Systems, Inc., Buffalo, New York.