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Identification of Two Cell Populations Required for Mouse Immunocompetence^1,2,

From the Department of Immunology, University of California, Berkeley, California, and Roswell Park Memorial Institute, Buffalo, New York

Abstract

Two cell populations participating in the mouse immune response to sheep erythrocytes (SRBC) are identified. Cells of one population can attach SRBC by means of surface receptors. These cells are present in bone marrow and spleen. Bone marrow receptor-bearing cells show synergism with thymus in response to SRBC in a cell transfer assay. Cells with receptors for antigen act as the direct cellular precursors of antibody-producing cells. Receptor-bearing cells may be fractionated from hematopoietic colony-forming units. The second cell population required for an immune response to SRBC acts in conjunction with receptor-bearing cells. This population is present in the peripheral lymphoid organs and can be fractionated from the receptor-bearing cells of these organs. This cell population is called the peripheral thymic population because its role in the immune response can be carried out by thymocytes.

Footnotes

¹ This work was supported by General Research Support Grant FR-05648 from the Division of Research Facilities and Resources, and Grant AI-08899, National Institute of Allergy and Infectious Diseases, National Institutes of Health.

² This paper and the subsequent one were taken from a thesis submitted in partial fulfillment of the requirements for a Doctor of Philosophy Degree in Immunology, University of California, Berkeley.

³ Predoctoral fellow National Science Foundation, on leave from the Department of Bacteriology and Immunology, University of California, Berkeley, at the Roswell Park Memorial Institute, Buffalo, New York.

⁴ Present Address: Department of Biochemistry, Stanford University, Stanford, Calif.