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The Effect of Heterologous Antilymphocyte Serum (ALS) on the Humoral Antibody Response to Salmonella Typhi "H" Antigen and Bovine Serum Albumin¹

From the National Institute for Medical Research, Mill Hill, London, England, and The Hospital for Special Surgery-Cornell University Medical Center, New York, N. Y.

Abstract

The immunosuppressive effects of heterologous ALS were studied in mice immunized with a bacterial (Salmonella typhi "H") and a protein (BSA) antigen. The principal conclusions are that depression of the primary response depends upon the administration of ALS prior to antigen, the magnitude of depression varies directly with ALS dose and inversely with antigen dose, the secondary response is little affected, and ALS pretreatment may set the stage for the induction of tolerance. These results are discussed in relation to current knowledge of the humoral immune response and the mode of action of ALS.

Footnotes

¹ This work was supported by Graduate Training Grant TI-AM 5414 from The National Institute for Arthritis and Metabolism, and by Grant AI-08750-01 from the National Institute of Allergy and Infectious Diseases, National Institutes of Health.

² Present address: The Hospital for Special Surgery, 535 East 70th Street, New York, N. Y. 10021.