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Production of Hypersensitivity in the Neonatal Mouse¹

From the Children's Cancer Research Foundation, Inc. and the Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115

Abstract

When the neonatal mouse is injected intravenously with a single dose of antigen, followed next day by an intravenous injection of Bordetella pertussis phase I vaccine, the following events take place: a) blast cells and foci of mitotic activity are seen in the spleen and thymus, and antibody-producing cells are detectable by the Jerne plaque technique by the 4th day of age; b) marked anaphylactic sensitivity does not become evident until the 5th week, and then persists at a maximum to the 10th week of age; and c) the anaphylactic sensitivity is not correlated with 19S or 7S antibody, precipitating antibody or antigen-binding capacity of the serum.

Footnotes

This work was supported in part by Research Grant FR-05526 from Division of Research Facilities and Resources, National Institutes of Health. Some of the results in this paper were reported at the annual meeting of the American Association of Immunologists, April 1969.