HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Henson, P. M. Search for Related Content PubMed Articles by Henson, P. M.

Release of Vasoactive Amines from Rabbit Platelets Induced by Antiplatelet Antibody in the Presence and Absence of Complement¹

From the Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California 92037

Abstract

Two actions of heterologous antiplatelet antibody on rabbit platelets have been described. The release of vasoactive amines from platelets by antibody in the absence of complement required an active energy-requiring participation on the part of the platelet and did not result in cytolysis. Antibody with at least two combining sites was needed, but no loss of activity occurred if the Fc piece was removed. In contrast, antibody in the presence of rabbit complement caused cytolysis and loss of internal constituents including cytoplasmic and lysosomal enzymes.

Footnotes

Publication No. 362 from the Department of Experimental Pathology, Scripps Clinic and Research Foundation. The work was supported by United States Public Health Service Grant AI-07007 and National Multiple Sclerosis Society Grant 459.

² Supported by United States Public Health Service Training Grant 5 TI GM 683.