HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Levy-Koenig, R. E. Articles by Paucker, K. Search for Related Content PubMed Articles by Levy-Koenig, R. E. Articles by Paucker, K.

Immunology of Interferons

I. Immune Response to Protective and Nonprotective Interferons

From the Virus Laboratories of Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19146, and the Influenza Department, Statens Seruminstitut, Copenhagen, Denmark

Abstract

Rabbits immunized with protective interferons prepared in allogeneic RK 13 and SIRC cells failed to develop neutralizing antibodies against either, although parallel groups of animals responded well to repeated injections of xenogeneic interferon prepared in L cells, which is non-protective for the rabbit host. All interferons which were xenogeneic and non-protective for guinea pigs elicited antibodies in that species. Significant levels of neutralizing antibodies appeared also in rabbits following immunization with two protective interferons derived from xenogeneic (human) cells. Immunologic analysis of human interferons elicited in four different types of cells revealed that minor antigenic variations may be detectable by means of antibody neutralization assays.

Footnotes

¹ Present address: P. O. Box 816, Santo Domingo, Dominican Republic.