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The Immunoglobulin Nature of the Antigen Recognition Site on Cells Mediating Transplantation Immunity and Delayed Hypersensitivity^1,2,

Laboratory of Immunogenetics, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia

Abstract

Pretreatment of normal adult mouse spleen cells, or peritoneal exudate cells from mice sensitized to DNP~CSA, with anti-immunoglobulin light polypeptide chain sera considerably suppressed the ability of these cells to induce the graft v8 host reaction or the transfer of delayed hypersensitivity. Anti-heavy chain sera did not cause this suppression. These results indicate that the antigen recognition site on lymphocytes involves an immunoglobulin light chain which is either free or bound to a new heavy chain type.

Footnotes

This investigation was supported by Research Grant AM11234-02 from the National Institute of Allergy and Metabolic Diseases, United States Public Health Service.

² This is Paper No. 1378 of the Walter and Eliza Hall Institute.

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