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The Journal of Immunology, 1970, 104: 738-745.
Copyright © 1970 by The American Association of Immunologists, Inc.
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Polyclonal 13S Human {gamma}G Immunoglobulin1

Ralph Heimer, Jose Martinez2 and John Abruzzo

Departments of Biochemistry and Medicine, Jefferson Medical College, Philadelphia, Pennsylvania

Abstract

Polyclonal 13S {gamma}G immunoglobulin, isolated from the serum of a patient with dermatomyositis, dissociated to 6.5S material possessing anti-{gamma}G activity. The Fc but not the Fab fragment, prepared from the 13.3S material, formed soluble complexes with autologous and isologous {gamma}G immunoglobulin. Aggregation rather than an antigen-antibody reaction appeared to be involved in the formation of the {gamma}G complex.

Footnotes

This work was supported by Grant T-473 from the American Cancer Society and Grants AM-11689 and HE-09163 from the National Institutes of Health.

2 Recipient of Special Fellowship, 1 F03 HE-39516, National Institutes of Health.






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