HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Lerner, A. M. Articles by Nolan, D. C. Search for Related Content PubMed Articles by Lerner, A. M. Articles by Nolan, D. C.

Complement-Requiring Neutralizing Antibodies in Herpesvirus Hominis Encephalitis^1,2,

Harper and Detroit General (Receiving) Hospitals and the Departments of Medicine, Microbiology and Pathology, Wayne State University School of Medicine, Detroit, Michigan

Abstract

Attempts at diagnosis of Herpesvirus hominis encephalitis by isolation of virus and a histologic search for type A intranuclear inclusion bodies from biopsies of the brain were made in eight patients who later were shown to have this disease. By these means a diagnosis was established in two of the eight patients.

In four of seven patients with herpesvirus encephalitis the initial serum showed titers of complement-requiring neutralizing antibodies to Herpesvirus hominis that were significantly greater (4 or more) than the titers of non-complement-requiring neutralizing antibodies. In another patient the CRN/N was 4 on the 15th day in the hospital. Complement dependence generally disappeared in later sera. The CRN/N was 4 or more during two of four episodes of recurrent mucocutaneous herpes simplex and in five of 17 persons without current recognized herpetic infection. Disparities in times of rise and fall in complement-fixing, complement-requiring and non-complement-requiring neutralizing antibodies indicate that the molecular species of the three immunoglobulins are distinct.

Footnotes

¹ This investigation was aided by PHS Training Grant AI-00261 and PHS Research Grant AI-05721 from the National Institute of Allergy and Infectious Diseases, and another grant from the Detroit General Hospital Research Corporation.

² Presented in part at the 26th annual meeting of the American Federation for Clinical Research, Atlantic City, New Jersey, May 3, 1969.

³ Dr. Lerner is Professor of Medicine and Associate in Microbiology and Pathology, Wayne State University School of Medicine, and Chief of Infectious Diseases, Detroit General Hospital, Detroit, Michigan.

⁴ Dr. Nolan is Trainee in Infectious Diseases and Instructor in Medicine.