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Products of Interaction of Antigen-Sensitized Leukocytes and Antigen: Further Characterization of the Mitogenic Factor¹

Section of Hematology and Immunology, Department of Medicine, University of California School of Medicine, San Francisco, California 94122

Abstract

Studies carried out on mitogenic factor produced by leukocytes from inbred guinea pigs in response to antigenic stimulation indicate that this factor is not transplantation antigen because it produces stimulation of normal leukocytes derived from guinea pigs of the same strain. Its activity was not enhanced by additional antigen. The factor is active on leukocytes derived from several sources, including spleen, lymph nodes, peripheral blood and thymus of outbred guinea pigs, and it is heat-stable.

Footnotes

This work was supported in part by a grant from the United States Public Health Service (AM-08527), and in part by Contract Nonr-3656(12) with the Office of Naval Research.

² At the time this work was done, Dr. Spitler was a Fellow in Hematology and Immunology, United States Public Health Service Training Grant HE-05677.