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The Antigenic Subunits of Influenza Viruses

II. The spectrum of cross reactions¹

From the Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan

Abstract

The breadth of the antibody response to antigenic subunits and whole virus vaccines was compared on sera against eight influenza A strains. The spectrum of cross-reactions for the two kinds of vaccine was statistically indistinguishable, both in antihemagglutinin and in neutralization tests. A strong negative correlation was found between the capacity of an antigen to give broad immunologic coverage and its proneness to being inhibited by heterologous sera. A model is proposed to account for the asymmetry of serologic crossing, and its theoretically and practical implications are discussed.

Footnotes

¹ This investigation was conducted under auspices of the Commission on Influenza, Armed Forces Epidemiological Board, and was supported by the United States Army Medical Research and Development Command, Department of the Army, under Contract DA-49-193-MD-2066.

² Present address: CSIRO Division of Animal Genetics, Sydney-North Ryde, Australia.