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Production of Anti-Hapten Antibodies by Several Classes of Lower Vertebrates¹

From the Department of Microbiology, College of Medicine, University of Florida, Gainesville, Florida 32601

Abstract

Antibody against DNP was demonstrated in several classes of lower vertebrates immunized with DNP-protein conjugates. In many cases, the antibody could only be detected by the neutralization technique employing DNP-T4 phage; however, teleosts in general appeared capable of synthesizing rather high levels of antibody to DNP.

Footnotes

This work was supported by National Institutes of Health Training Grant 5TI AI 0128-09, General Research Support Grant FR-05362-06, and by Office of Naval Research Contract Nonr 552(07).