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Differentiation of Human IgM Subclasses by the Ability to Interact with a Factor Resembling the First Component of Complement¹

From the Division of Hematology and Immunology and the Department of Microbiology, University of California Medical Center, San Francisco, California

Abstract

Two groups of human IgM proteins are described. One group interacts with a heat-labile component of rabbit or human serum which has characteristics similar to C'1q. The second group fails to interact with this factor. This grouping is not related to or chains or to previously described differences in human IgM molecules. Such a division may provide a tool for the identification of µ chain genetic markers.

Footnotes

This study was supported by grants from the National Institutes of Health (AM 08527) and the American Cancer Society (T-386A).

² Present address: Division of Immunology, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio.