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Immune Mechanisms of Reversed Type Reaginic Hypersensitivity¹

From the Children's Asthma Research Institute and Hospital, Denver, Colorado

Abstract

F(ab')₂ fragments of anti-E obtained by pepsin digestion and reduced-alkylated anti-E induced reversed type erythema-wheal reactions in normal individuals and released histamine from leukocytes, whereas Fab' fragments of the antibody failed to do so. The requirement of two antibody-combining sites in anti-E for induction of the reversed type allergic reactions suggested that bridging of two cell-bound E molecules by anti-E is the initial step of the reactions. On a molar basis, the original antibody and F(ab')₂ fragments were comparable in their ability to induce the reversed allergic reactions, but the C'-fixing activity of the fragments was only 0.4% that of the undigested antibody. The results strongly suggested that C' is not essential for induction of the reversed type reactions.

Footnotes

This work was supported by Research Grant A1-04985 from the United States Public Health Service.

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