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Rabbit Autoantibodies to Aorta¹

From the Department of Microbiology, School of Medicine, State University of New York at Buffalo, Buffalo, New York 14214

Abstract

Antisera of rabbits immunized with antigenic preparations of bovine and human aortic intima reacted also with extracts of rabbit aorta, and two antigens characteristic of this tissue could be detected by these antisera. Two analogous antigens could also be identified by using the antisera of rabbits immunized with pooled rabbit aorta preparations in Freund's adjuvant. One of these antigens was a thermolabile component with fast electrophoretic mobility, presumably a protein; the other was a thermostable ethanol-insoluble component closely related to previously described tissue-specific BE antigens. Reactions with antigenic preparations derived from the antibody-producing animal provided evidence for the autoantibody nature of the antibodies under investigation.

Footnotes

This study was supported by United States Public Health Service Research Grant CA-02357 from the National Cancer Institute, National Institutes of Health.

² Recipient of fellowships from NATO and The United States Health Foundation of Western New York.

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