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Prolonged Bursal Lymphocyte Depletion and Suppression of Antibody Formation Following Irradiation of the Bursa of Fabricius¹

From the Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, and Department of Microbiology, Hahnemann Medical College and Hospital, Philadelphia, Pennsylvania 19104

Abstract

Destruction of lymphoid follicles with lasting lymphocyte depletion was observed when the bursa of Fabricius of day-old chicks was exposed to 1000-r doses of x-radiation on the 1st and 7th day of post-embryonic life. Irradiated bursas did not reach more than 2% of the control bursa weights over a 90-day period of observation. The numbers of germinal follicles and plasma cells were decreased in the spleens and cecal tonsils of bursa-irradiated (BI) birds. In addition, BI birds demonstrated a diminished antibody-producing capability to selected antigens, and several of them showed a transient G dysgammaglobulinemia. No histologic differences between the thymuses of bursa-irradiated and non-irradiated birds were detected.

Footnotes

This work was supported by Public Health Service Grant 5-RO-1 AM-11693 from the National Institutes of Arthritis and Metabolic Diseases (to W. T. W.) and by American Cancer Society Institutional Grant IN-8-H (to W. P. W.).