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Protein a from Staphylococcus Aureus

IX. Complement-fixing activity of Protein A-IgG complexes¹

From the Department of Pharmaceutical Biochemistry, the Wallenberg Laboratory, University of Uppsala, Uppsala, Sweden

Abstract

Protein A from Staphylococcus aureus added to guinea pig serum inactivates the hemolytic complement (C') of the serum. Preformed aggregates of protein A and guinea pig or human IgG inactivate complement. It is probable that the complement-consuming property of protein A is due to its ability to combine with the Fc part of the IgG, thus rendering the IgG complement-fixing. The possibility that the in vivo sensitivity-promoting activity of protein A is due to its ability to activate the complement system is discussed. A hemagglutination technique was developed in order to determine small amounts of protein A.

Footnotes

This work was supported by grants from the Medical Faculty, University of Uppsala, to G.S., from Riksförbundet mot Allergi, to J.S. and G.S., and from Knut och Alice Wallenbergs Stiftelse, the Swedish Medical Research Council (B69-13X-2518-01A) and the Swedish Cancer Society (56-B68-03X) to J.S.