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The Immunoglobulins of Equine Colostrum and Parotid Fluid¹

From the Department of Microbiology, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania 19104

Abstract

Chemical fractionation and antigenic analysis have shown equine parotid fluid and equine colostrum to contain G, G(T) and M immunoglobulins. The immunoglobulins found in the secretions were comparable in size and electrophoretic mobility to the corresponding serum immunoglobulins. Parotid fluid G(a,b,c) and G(T) were purified by gel filtration, ion exchange chromatography and sucrose density gradient ultracentrifugation. Purified parotid fluid G(a,b,c) obtained from a hyperimmunized horse was found to contain precipitating antibodies directed to proteins used in the immunization of the horse. The ratio of G(a,b,c) to G(T) immunoglobulins of parotid fluid and colostrum was close to the ratio of these immunoglobulins found in the donor horse's serum. There appears to be little or no secretory A immunoglobulin in equine parotid fluid or colostrum that is comparable in size and antigenicity to that found in some other mammals.

Footnotes

This investigation was supported in part by a United States Public Health Service Research Grant (HE-06293) from the National Heart Institute and in part by a United States Public Health Service Training Grant (5-T1-A1-204) from the National Institute of Allergy and Infectious Diseases.

² Present address: Department of Oral Biology, School of Dentistry, State University of New York at Buffalo, Buffalo, N. Y. 14226.

³ Recipient of a Public Health Service Research Career Award (5-KG-A1-14,012) from the National Institute of Allergy and Infectious Diseases.