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Non-Complement-Fixing IgM Antibodies in the Guinea Pig¹

From the Department of Microbiology, University of California School of Medicine, San Francisco Medical Center, San Francisco, California

Abstract

The direct and indirect C1 fixation and transfer techniques were used to estimate the amounts of complement-fixing and non-complement-fixing IgM antibodies present in serial samples of serum taken from individual guinea pigs after immunization with rabbit erythrocytes, sheep erythrocytes, boiled sheep erythrocyte stroma, or bovine globulin. In most cases there was an increase in the relative proportion of non-complement-fixing IgM with time after immunization, and the ratio of non-complement-fixing antibody to complement-fixing antibody ranged from approximately 1 to greater than 10. Most antibody preparations contained several times as much non-complement-fixing IgM as complement-fixing IgM.

Footnotes

Supported in part by Public Health Service Grants AI 06464 and 5 T01 AI 00299 from the National Institutes of Health.

² Second-year medical student.