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The Journal of Immunology, 1969, 103: 79-86.
Copyright © 1969 by The American Association of Immunologists, Inc.
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The Immunologic Response of the Mouse to Aerosols of an Attenuated Encephalomyocarditis Virus Strain1

Catherine M. Prato and Thomas G. Akers2

From the Naval Biological Laboratory, School of Public Health, University of California, Berkeley, California

Abstract

The antibody response, interferon synthesis, viremia and replication of virus in the lungs of mice following aerogenic immunization with mengovirus-37A were studied. Virus titers in blood and lungs were maximal at day 1, whereas interferon activity was greatest at day 7 after aerosol exposure. Hemagglutination-inhibition (HAI) activity (2-ME sensitive) was detected on day 6, neutralizing antibodies by day 9 (also 2-ME sensitive) and complement fixation tests were positive on day 12. After day 12, 2-ME resistant HAI and neutralizing antibodies were observed. Maximum HAI and neutralizing antibody titers occurred on day 31.

The usual pattern of early 19 S response followed by 7 S antibody formation was observed following aerogenic immunization of mice with mengo virus-37A. However, the time required for antibody to appear was longer than that noted in other immunization studies using other routes of vaccination.

Footnotes

This investigation was supported by the Office of Naval Research and the Bureau of Medicine and Surgery, United States Navy, under a contract between the Office of Naval Research and the Regents of the University of California. Reproduction in whole or in part is permitted for any purpose of the United States Government.

2 Naval Medical Research Unit No. 1, University of California, Berkeley, California.






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