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The Journal of Immunology, 1969, 103: 114-119.
Copyright © 1969 by The American Association of Immunologists, Inc.
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A Graft vs. Host Reaction in a Xenogeneic Combination: The Reaction of Murine Cells in Rats1

Wasfy Saleh2, Lloyd D. MacLean and Julius Gordon3

From the Department of Experimental Surgery, McGill University, Montreal, Canada

Abstract

The injection of viable immunologically competent mouse cells under the kidney capsule of cyclophosphamide-treated rats produces a localized graft vs. host (GVH) reaction, manifested by infiltration and destruction of the kidney cortex. The reaction, shown to be a GVH reaction by cytological analysis, can be inhibited by antisera specific to the cells injected.

Footnotes

This work was supported by grants from the John A. Hartford Foundation, Inc. and the Medical Research Council of Canada.

2 Fellow of the Medical Research Council of Canada.

3 Research Associate of the Medical Research Council of Canada.






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