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Some Antigenic and Physical Properties of Virus-Like Particles in Sera of Hepatitis Patients

From the Division of Biologics Standards and the National Institute of Arthritis and Metabolic Diseases, National Instiutes of Health, Bethesda, Maryland 20014

Abstract

The Australia antigen was detected by Blumberg, Alter and Visnich in 1965 in human sera by formation of a precipitin line in Ouchterlony gel diffusion slides (1). Antibodies used to detect the antigen are found in sera from patients who have received multiple transfusions The antigen is rare in healthy Americans, but common in patients with either infectious or serum hepatitis, patients with Down's syndrome who have anicteric hepatitis, patients with leukemia or leprosy, and apparently healthy persons in certain tropical populations (2). Bayer, Blumberg and Werner described 19 to 21 mµ particles in antigen-containing serum fractions from sucrose gradients (3). The particles were aggregated by the same sera that precipitated the antigen. Blumberg and co-workers and Prince have suggested that the antigen is a virus or is intimately associated with a virus that is responsible for hepatitis in man (2–5).

This article has been cited by other articles:

				G. N. Vyas and N. R. Shulman Hemagglutination Assay for Antigen and Antibody Associated with Viral Hepatitis Science, October 16, 1970; 170(3955): 332 - 333. [Abstract] [PDF]

				N. R. Shulman and L. F. Barker Virus-like Antigen, Antibody, and Antigen-Antibody Complexes in Hepatitis Measured by Complement Fixation Science, July 18, 1969; 165(3890): 304 - 306. [Abstract] [PDF]