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Density of BAI Strain A Avian Leukosis Virus-Antibody Complexes Relative to Antigen-Antibody Ratio¹

From the Department of Surgery, Duke University Medical Center, Durham, North Carolina 27706

Abstract

Immune complexes of differing antibody-virus ratios were prepared with rabbit anti-BAI strain A avian leukosis virus and the homologous antigen by means of the quantitative precipitin reaction. These complexes were centrifuged to their equilibrium densities on potassium tartrate gradients and the results were compared with the analogous properties of free virus and normal rabbit globulin centrifuged under the same conditions. The equilibrium density of the complexes was greater than that of the free virus and was directly proportional to the antibody-virus ratio. Normal rabbit globulin was not sedimented significantly under the same experimental conditions.

Footnotes

¹ This work was aided by Research Grant C-4572 to Duke University from the National Cancer Institute; by the Annie Mabel Sherris Memorial Grant for Cancer Research from the American Cancer Society, Inc.; and by the Dorothy Beard Research Fund.