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Local Plasmacytopoiesis in Delayed Hypersensitivity Reactions¹

From the Departments of Pathology and Medicine, Massachusetts General Hospital, the Department of Pathology, Harvard Medical School, Boston, Massachusetts and the Division of Ophthalmology (Surgery), Vanderbilt University School of Medicine, Nashville, Tennessee

Abstract

The cytologic features of delayed hypersensitivity reactions in the cornea revealed a vigorous plasmacytic response superimposed upon an initial "classic" delayed reaction. In hapten-specific delayed reactions (induced following systemic sensitization with azobenzenearsonate (ABA)-tyrosine conjugates by intracorneal injection of the hapten conjugated to a heterologous carrier protein), the plasmacytic response involved, in part, an accelerated primary reaction to the heterologous carrier. Local plasmacytopoiesis resulting from delayed reactions may be significant in the pathogenesis of cell-mediated allergic injury.

Footnotes

This work was supported by United States Public Health Service Grants AI-05550, NB-05935 and NB-06977.

² Recipient of career development award K3-AI-2040.

³ Address correspondence to: Dr. James J. Daly, Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts 02114.