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Quantitative Precipitin Analysis of Influenza Virus Host Antigen and of Sulfated Mucopolysaccharides of Chicken Embryonic Allantoic Fluid¹

From the Department of Microbiology, Columbia University, College of Physicians and Surgeons, and the Department of Chemistry, Belfer Graduate School of Science, Yeshiva University, New York, New York

Abstract

The composition and immunologic reactions of sulfated mucopolysaccharide antigens from chicken chorioallantoic fluid were examined. Differences in NANA content between host antigen (HF) and saccharides from both vaccine supernatant fluid and from normal CA fluid were ascribed to the preparative methods used. Reduction of disulfide bonds altered the immunologic reactivity of HF without changing its qualitative analytical properties. The possible contributions of NANA, fucose and protein to the antigenic determinants of these macromolecules are considered.

Footnotes

This investigation was supported by the National Institutes of Health, United States Public Health Service, Grants AI-03168 and HD-02646.