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Development of Humoral and Cell-Mediated Immunity to Lymphocytic Choriomeningitis Virus in the Mouse¹

From the Institute of Medical Microbiology, University of Copenhagen, Copenhagen, Denmark

Abstract

The immune response in the mouse to LCM virus has been studied by measuring the CF-antibody titers and the elimination of viremia in syngeneic tolerant virus-carrier mice after adoptive immunization. This latter phenomenon has previously been shown presumably to be the expression of a specific cell-mediated immunity to the virus.

With regard to the humoral response in the adult mouse, it is shown that CF antibodies are formed by the end of 1 week after primary vaccination with LCM virus. They rapidly increase to titers which adjust to a constant level, presumably for the rest of the animal's life. This constant level is the same in secondarily vaccinated or hyperimmunized mice and is unaltered by a booster dose of virus. This constant immunity is most probably caused by a continuous stimulation from viral foci, especially in the kidneys. After adoptive immunization of syngeneic tolerant virus-carrier mice, lymphoid cells from such immune mice are able to give an enormously enhanced immune response. The CF antibodies from both the immune and the adoptively immunized mice are all 2-ME insensitive, indicating their 7 S character.

It is shown that the cell-mediated immunity to LCM virus after primary vaccination develops almost synchronously with the humoral response. During the first weeks of their development, a clear-cut dissociation of the immune responses may be found.

Footnotes

This research was supported by grants from the Einar Willumsen's Memorial Fund and the Danish Cancer Society.

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