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Studies of the Macrophage Inhibition Test

I. Comparison of the Skin and Cell Migration Reactions During the Course of Development of Delayed Hypersensitivity¹

From the Department of Medical Microbiology, Stanford University School of Medicine, Stanford, California 94305

Abstract

The course of development of delayed skin reactivity in vivo and inhibition of peritoneal cell migration in vitro were compared in guinea pigs vaccinated with diphtheria toxoid (Dtd) and human globulin (HGG) in complete Freund's adjuvant. A modification of the capillary tube method of migration-inhibition provided a simple and reproducible system that was susceptible of statistically analysis and that allowed the detection of low levels of reactivity.

Delayed skin reactivity appeared earlier and developed more rapidly than migration-inhibition in the first 2 weeks after immunization. Studies with graded doses of Dtd later after sensitization indicated that, once sensitivity was well established, the in vivo and in vitro reactivities followed the same course.

Arthus reactivity in skin test sites did not coincide with maximum delayed skin reactivity or migration-inhibition.

Footnotes

This investigation was supported by Research Grant AI-01178 and Training Grant AI-82 from the National Institute of Allergy and Infectious Diseases, and by a research grant from the San Francisco Foundation.

² Supported by a fellowship from the Ministry of Health and Welfare, Venezuela.

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